Nitric-Oxide-Mediated Vasodilation of Bioactive Compounds Isolated from Hypericum revolutum in Rat Aorta
نویسندگان
چکیده
منابع مشابه
Nitric oxide-mediated vasodilation in human pregnancy.
The maternal circulation vasodilates during pregnancy. We investigated the contribution of nitric oxide to this vasodilatation. Using venous occlusion plethysmography, we measured the effect of nitric oxide synthase inhibition on hand blood flow during human pregnancy. We compared the response to a brachial artery infusion of the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine (L-NMM...
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OBJECTIVES Glibenclamide was found to act as both a selective ATP-sensitive K(+) channel blocker and a vasorelaxant. The exact mechanisms underlying the relaxant effect of glibenclamide are unknown. The present study was designed to examine the role of endothelium/nitric oxide in glibenclamide-induced relaxation in rat isolated aortic rings. METHODS A combination of experimental approaches in...
متن کامل6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation
The aim of the present study is to investigate the effect and potential mechanism of action of 6-gingerol on alterations of vascular reactivity in the isolated aorta from diabetic rats. Male Wistar rats were divided into two experimental groups, control and diabetics. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg kg(-1)), and the rats were left for 10 weeks...
متن کاملLipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta
BACKGROUND Intravenous lipid emulsion has been used to treat systemic toxicity of local anesthetics. The goals of this in vitro study were to determine the ability of two lipid emulsions (Intralipid® and Lipofundin® MCT/LCT) to reverse toxic dose local anesthetic-induced vasodilation in isolated rat aortas. METHODS Isolated endothelium-denuded aortas were suspended for isometric tension recor...
متن کاملFlow-mediated vasodilation partially reflects nitric oxide-mediated endothelial function.
To the Editor: In this Point:Counterpoint series, Green and Tschakovsky and Pyke address the issue of whether flowmediated dilation (FMD) reflects nitric oxide (NO)-mediated endothelial function (1). However, this question is difficult to answer. It has been conclusively shown that FMD of the brachial artery after 5 min of wrist cuff occlusion can be entirely abolished by the NO synthase (NOS) ...
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ژورنال
عنوان ژورنال: Biology
سال: 2021
ISSN: 2079-7737
DOI: 10.3390/biology10060541